Other Names:
- Chronic urticaria with gammapathy
- Chronic urticaria with macroglobulinemia
Description
Schnitzler syndrome is a rare autoinflammatory condition. Signs and symptoms of the condition vary but may include urticaria; recurrent fevers; joint pain and inflammation; organomegaly (abnormally enlarged organs); and/or blood abnormalities. The exact underlying cause of the condition is unknown; however, most cases occur sporadically in people with no family history of the condition. Treatment is focused on alleviating the signs and symptoms associated with the condition and may include various medications and/or phototherapy.
Symptoms
The signs and symptoms of Schnitzler syndrome vary but may include:
- Red raised patches of skin (urticaria) that may become itchy
- Recurrent fevers
- Join pain and inflammation
- Organomegaly (enlarged internal organs) often involving the lymph nodes, liver and/or spleen
- Bone pain
- Blood abnormalities
- Muscle aches
- Fatigue
- Weight loss
People affected by Schnitzler syndrome also have an increased risk of developing certain lymphoproliferative disorders.
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